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The mechanism of the release of encapsulated lidocaine from spherical nanoparticles based on poly(D,L-lactic acid) polymer carrier (PLA) was studied through mathematical modelling. The drug was incorporated in the PLA matrix with particle sizes from approximately 250 to 820 nm and corresponding loadings varying from about 7 to 32% (w/w). The rate of release correlated with the particle drug loading...
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