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Objective:Inhibiting Aβ generation is a prime therapeutic goal for preventing or treating Alzheimer disease. Here we sought to identify any disease‐modifying properties of an azaindolizinone derivative, spiro[imidazo[1,2‐a]pyridine‐3,2‐idan]‐2(3H)‐one (ST101 or ZSET1446).
Methods:The effects of ST101 were studied in 3xTg‐AD mice and young cynomolgus monkeys using a combination of biochemical and...
Objective:Intracellular amyloid β‐protein (Aβ) contributes to neurodegeneration in Alzheimer disease (AD). Apomorphine (APO) is a dopamine receptor agonist for Parkinson disease and also protects against oxidative stress. Efficacy of APO for an AD mouse model and effects of APO on cell cultures are studied.
Methods:The triple transgenic AD mouse model (3xTg‐AD) has 2 familial AD‐related gene mutations...
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