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Objective: The pathogenesis of vulvar vestibulitis syndrome remains unknown but may be related to a localized chronic inflammation. The relation between this syndrome and a polymorphism at position +3953 in the interleukin-1β gene was examined. Allele 2 of this gene has been associated with increased pro-inflammatory immunity. Study design: Buccal or vestibular swabs from 59 women with strictly defined...
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