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Multicolumn countercurrent chromatography is capable of improving the performance of many chromatographic batch separations; however, the right process has to be selected for the right purpose. This chapter presents different countercurrent chromatography processes according to their applicability in biopharmaceuticals production. The increased capacity utilization of CaptureSMB leads to significant...
This chapter contains sections titled:
Introduction
Product Variants and the Separation Problem
Definition of Performance Parameters
Gradient Chromatography for Biomolecules
Continuous Chromatography to Increase Productivity
The MCSGP Process
Upgrades for Continuous Processes to Improve Stability
Impact of Increasing Fermentation Titers
Outlook
Acknowledgments
References
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