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Introduction: Ischemic injury to intestine and kidney causes epithelial cell detachment and subsequent functional impairment. Epithelial regeneration and recovery involves incompletely understood events, including cell adhesion and spreading to reseal breaches in epithelial continuity. Previous data suggests the basement membrane protein laminin-5 and its a3b1-integrin receptor are involved in recovery...
Introduction: Ischemic stress activates mitogen-activated protein kinases (MAPKs) in intestinal epithelia, a response that directs cell fate after injury. We reported that ischemic stress triggers ligand-independent activation of the epidermal growth factor receptor (EGFR), an event associated with downstream activation of MAPK. This study examines the role of EGFR-associated adaptor proteins SHC...
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