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Large evidence showing an association between depression and tobacco smoking is known. Nicotine is the active chemical responsible for smoking addiction, and its withdrawal may induce in smokers greater sensitivity to stress. Our aim has been to investigate the links between tobacco addiction and depression by studying the long-term effects of repeated administration of nicotine followed by dependence,...
Rationale. Hypericum perforatum is used as a natural antidepressant, and other antidepressants have been marketed to aid in smoking cessation. Objective. We investigated the effects of an extract of Hypericum perforatum (Ph-50) on withdrawal signs produced by nicotine abstinence in mice. Methods. Nicotine (2mg/kg, four injections daily) was administered for 14 days to mice. Different doses of Ph-50...
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