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Linoleic-acid (LA) is covalently conjugated to carboxymethyl-chitosan via a 1-ethyl-3-(3-dimethylaminopropyyl)-carbodiimide-mediated (EDC-mediated) reaction to generate self-aggregated chitosan nanoparticles by sonication. The average diameter of the particles is 417.8nm, with a size range from 222.8nm to 1028nm. Adriamycin (ADR) can be physically entrapped into the self-aggregates. The drug loading...
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