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XL092 is a potent ATP‐competitive inhibitor of multiple receptor tyrosine kinases that is undergoing clinical development for the treatment of lung cancer. In this study, an LC triple quadrupole mass spectrometry method was established to measure XL092 in monkey plasma. A Waters ACQUITY UPLC BEH C18 column was used for chromatographic separation. The mobile phase consisted of water containing 0.1%...
Aesculetin, a coumarin compound present in the sancho tree and chicory, exhibits excellent antioxidant and anti‐inflammatory activities in the vascular and immune system. In this study, a rapid and sensitive ultra‐high performance liquid chromatography electrospray ionization–tandem mass spectrometry (UHPLC–ESI–MS/MS) method was established and validated for the determination of aesculetin in rat...