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Mucopolysaccharidosis (MPS) type IIIB is a genetic deficiency of α‐N‐acetylglucosaminidase, inducing accumulation of partially degraded heparan sulfate (HS) oligosaccharides in tissues. In the central nervous system, this accumulation is associated with microglial activation, neurodegeneration, and oxidative stress. We have already shown that HS activates microglial cells through toll‐like receptor...
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