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C6-Schiff bases derivatives of chitosan were synthesized for the first time. C2-amino groups and C3-hydroxy groups were firstly protected by CuSO4·5H2O, and the C6-hydroxy was then transformed into aldehyde, which then reacted with anilines through nucleophilic addition to introduce the CN group at C6-position in chitosan chain. Finally, C6-Schiff bases derivatives of chitosan were got by the deprotection...
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