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Recent studies demonstrated that miR-137 is downregulated in various tumors, and that it functions as a tumor suppressor. miR-137 could be silenced by its aberrant promoter hypermethylation. The purpose of this study was to investigate the significance of MIR137 promoter methylation on its expression in lung cancer.Lung cancer cell lines were treated with either a DNA methyltransferase inhibitor (5-azacytidine,...
The aim of this study was to report the long-term clinical experience with lung stereotactic ablative radiotherapy (SABR).Between April 2004 and December 2011, 58 of 92 consecutive lung SABR cases were treated with a curative purpose and were eligible for inclusion. Forty patients were treated for primary lung cancer, and eighteen were treated for locally confined recurrent tumors. The majority of...
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