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Helicobacter pylori–induced gastric carcinogenesis has been linked to the microbial oncoprotein cytotoxin-associated gene A (CagA). Spermine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H 2 O 2 , which causes apoptosis and DNA damage. We determined if pathogenic effects of CagA are attributable to SMO. Levels of SMO, apoptosis, and DNA damage (8-oxoguanosine)...
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