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Administration of endotoxin induces hyperlipidemia in experimental animals. In the current study, we investigated whether endotoxin alters hepatic low density lipoprotein receptor (LDL-R) expression in rats. We found that administration of endotoxin suppressed hepatic LDL-R expression in a dose- and time-dependent manner. Eighteen hours after intraperitoneal injection of increasing amounts of endotoxin,...
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