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Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase‐responsive charge‐reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells but does not activate...
An esterase‐responsive positive‐to‐negative charge‐reversal polymer is developed for selective gene expression among tumor cells via differentiated dissociation of polyplexes by their intracellular esterase activities, such that TRAIL suicide gene is highly expressed in cancer cells, inducing cancer cell death, but not expressed in fibroblasts. This pacifies them not to secrete the tumor growth and...
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