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The nuclear factor κB (NF‐κB) transcription factor family plays a key role in regulation of the inflammatory pathway in response to different physiological stimuli starting from development to ageing. The dysregulation of NF‐κB has been associated with many pathological conditions like inflammatory diseases, neurodegeneration, metabolic diseases and various kinds of malignancies. The NF‐κB pathway...
BACKGROUNDSignal transducer and activator of transcription (Stat)‐3 and nuclear factor‐kappa B (NF‐κB) are important signaling pathways constitutively activated during inflammation. We previously reported that high‐fat diet (HFD) intake induces oxidative stress in the prostate through elevated expression of NADPH oxidase subunits causing NF‐κB activation. We sought to determine whether Stat‐3 is involved...
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