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Cytosolic Ca 2+ elevations are known to be involved in triggering apoptosis in many tissues, but the effect of sustained enhancement of Ca 2+ influx on apoptosis in β cells remains unknown. We have found that the viability of RINm5F cells is decreased dose-dependently by continuous exposure to glibenclamide at concentrations from 10 −7 to 10 −4 M, and that this effect...
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