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Autophagy‐related 4B (ATG4B) is a protease required for core machinery of autophagy. Phosphorylation of ATG4B promotes autophagy and is correlated with poor outcome of cancer. However, little is known about the upstream kinases for ATG4B phosphorylation and their association with clinical outcomes of cancer patients. Through siRNA library screening, MAP3K11 was identified as a potential kinase that...
The aim of this study was to assess the protective effect and potential mechanism of melatonin against bisphenol A (BPA)‐induced apoptosis and oxidative damage in FLK‐BLV cells. The results showed that BPA reduced cell viability in a dose‐ and time‐dependent manner, caused cell shrinkage and induced oxidative stress and apoptosis in FLK‐BLV cells, which were effectively reversed by melatonin. In addition,...