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Recent studies suggest that multiple myeloma (MM) induces proliferation and expansion of bone marrow (BM) mesenchymal stem cells (MSCs), but others showed that MM cells induce MSC senescence. To clarify the interaction between MM and MSCs, we exploited our established MSC gene signature to identify gene expression changes in myeloma MSCs and associated functional differences. Single MSCs from patients...
In multiple myeloma research, the GEP70 model is known to be capable of predicting a high risk patient group for disease progression based on the expression levels of 70 selected genes measured at baseline. The model consists of a continuous gene score that is a linear combination of the 70 genes along with a cutoff, such that patients with a score greater than the cutoff are categorized as high risk...
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