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Introduction: Cytotoxic T lymphocytes (CTL) are potent effectors of the cellular immune response which could provide long term protective immunity if induced by appropriate antitumor vaccines. CTL recognize 8-14 amino acid long peptides processed intracellularly and presented by MHC class I molecules. A well characterised example of a potential tumor antigen in childhood pre-B Acute Lymphoblastic...
Islet transplantation is a method to restore insulin secretion in IDDM patients but unfortunately the rate of graft failure is until now unacceptably high. We have recently reported the presence of high endotoxin activity in collagenase P, the enzyme commonly used to isolate islets for transplantation; this, together with the finding of CD14 (endotoxin/LPS receptor) on the islet cell surface led...
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