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Drinking water exposure to arsenic is known to cause immunotoxicity. Our previous studies demonstrated that monomethylarsonous acid (MMA+3) was the major arsenical species presented in mouse thymus cells after a 30 d drinking water exposure to arsenite (As+3). MMA+3 was also showed to be ten times more toxic than As+3 on the suppression of IL-7/STAT5 signaling in the double negative (DN) thymic T...
Environmental arsenic exposure is a public health issue. Immunotoxicity induced by arsenic has been reported in humans and animal models. The purpose of this study was to evaluate mechanisms of As+3 and MMA+3 toxicity in mouse thymus cells. Because we know that MMA+3 inhibits IL-7 signaling in mouse bone marrow pre-B cells, we studied the influence of As+3 and MMA+3 on T cell development in the thymus...
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