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The mutation p.K27M in H3F3A (H3 K27M mutation) is mainly detected in diffuse midline glioma. However, recent studies have demonstrated that H3 K27M mutation could also be observed in a subset of gangliogliomas. Importantly, most H3 K27‐mutated ganglioglioma cases also harbor BRAF V600E mutation. Herein, we report a rare case of H3 K27M‐mutated ganglioglioma grade 3 without BRAF mutation arising in...