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The transporter associated with antigen processing (TAP) gene products transport peptides from the cytosol to the endoplasmic reticulum for processing by the immune system. We hypothesized that polymorphisms within the TAP genes may influence measles vaccine antigen processing and hence antibody response. TAP genotypes were determined for subjects who were measles vaccine nonresponders (n=32) and...
Objective: To describe and analyze the reporting of major factors impacting interpretation of vaccine efficacy and immunogenicity trials in recently published studies.Data sources: Selected studies (n=83) published during a two year period in five journals most likely to contain vaccine trials.Study selection: Studies designed as prospective efficacy or immunogenicity clinical trials in human subjects,...
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