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The transportation and distribution of living bacteria particles were analyzed in a computational fluid model with the mobile phase of human urine, which resembles the pathogenesis of bacterial urine tract infections with complications of urethral calculi. Interrelated processes contributing to the mass transport and bacteria growth in the urine flow were evaluated. The two-dimensional model was also...
Cognitive networks rapidly proliferating into all aspects of computing and communication. Some of them are specially designed for the people with specific ability. However, very few are designed with assistance of the people with disability and elderly who need help during networking. The goal of this project is to study network accessibility issues and their impact in such cognitive network design...
Increasing power delivery and performance requirements for next-generation Intel microprocessors has led to the need for a high-capacitance low-inductance decoupling option very close to the die. An embedded array capacitor (EAC) is a large array capacitor embedded in the high-density interconnect (HDI) substrate core and provides a low-inductance path to the die. This paper describes technology development...
A service-based model of human signal-molecule-profiling database (HSMPD) was proposed to prompt data acquisition of medical information from blood tests in traditional healthcare systems and to make the data be naturally converted into Health IT (HIT) services through the translational bioinformatics (TBI) community. A self-motivated mechanism to minimize the project investment was designed. The...
Signal molecular profiling (SMP) in serum can reveal abundant medical information about the human body. The construction of a human signal-molecular-profiling database (HSMPD) will greatly prompt the research of medical science. However, some challenges hinder the construction of HSMPD. A promising strategy is proposed to provide a convenient way for the establishment of HSMPD. Firstly, a low-cost...
The cell-based microfluidic chip was designed and fabricated as a low-cost detector to continuously monitor toxicants in drinking water or human urine samples, which is expected to be an important component of a household health monitoring system in the future. The bioluminescent bacterium, Vibrio Fischeri, was selected to validate the function of device. Water samples and Vibrio fischeri cells were...
Bacterial waterborne pathogens often threaten the water safety of the drinking water system. In order to protect the health of home users, a household lab-on-a-chip (LOC) device was developed for online monitoring bacterial pathogens in drinking water, which are in accord with green design concept. The chip integrated counter-flow micromixers, a T-junction droplet generator and time-delay channels...
The present medical technology cannot radically cure many chronic diseases, which often involved the interaction between different organs or systems in human body. Since signaling molecules, such as hormones, neurotransmitters, cytokines etc., play a key role in the communication of different organs, signaling molecular profiling (SMP) could provide an intelligible overview of the systems inside human...
As the present technology of cancer treatment cannot cure the diseases, a prospective therapy, named ‘systemic therapy’, brings forth a new trend in cancer treatment. The aptamer-NASBA-based lab-on-a-chip (LOC) for systemic therapy was designed, fabricated and tested as an ultra-sensitive tool to monitor signaling molecular profiling in serum samples. The chip is divided into four parallel functional...
In this paper, a thermal biosensor based on the infrared radiation energy is proposed for calorimetric measurement of biochemical reactions. Having a good structure design combined with MEMS technology as well as employing the Si /SiGe quantum well sensing material with a high TCR and low 1/f noise, the sensor shows potentials to be high sensitive and real-time. The urea enzymatic reaction was tested...
In this paper, a new concept of MEMS based biosensor is presented as a promising solution for the ultra- low level and real time detection of waterborne pathogens. This novel infrared biosensor employs the SiGe/Si quantum well thermistor with a high TCR and low 1/f noise to achieve a high sensitive detection through its resistance change with the absorption of infrared radiation from the dark quencher...
Water environmental problems usually make a global threat to human beings. There has been a growing demand for convenient and sensitive tools to detect the biomarkers in aquatic environment. Here, an improved Lab-on-a-chip (LOC) based on the real-time Immuno-NASBA (nucleic acid sequence-based amplification) assay was designed and studied. The disposable Immuno-NASBA chip is modeled as a 384-well ELISA...
Microfluidic devices can automatically perform multiple laboratory functions on a single, compact and integrated chip. This study demonstrates that a new concept lab-on-a-chip system is able to quantify soluble biomarkers in water environment with femtomolar sensitivity, high specificity and ability for middle throughput monitoring. This system is based on a new assay named ‘real-time immuno-nucleic...
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