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L'effet cytotoxique des camptothecines (CPTs) est la consequence de collisions entre les complexes clivables (CC) topoisomerase I (top I)-ADN stabilises par la CPT et la fourche de replication de l'ADN. L'objectif de cette etude fut d'isoler des determinants cellulaires de l'activite des CPTs, independents du phenotype top I.Deux lignees de cancer colique humain, SW620 et KM12, qui ont une proteine...
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