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Recent studies introduced the concept that reactive oxygen species (ROS) may be a major factor in the progressive deterioration of bladder function induced by benign prostatic hyperplasia in men and following partial outlet obstruction in animals. We determined whether bladder contraction sensitivity to ROS changes with aging. Using H 2 O 2 to simulate ROS damage we compared the sensitivity...
In the current study, the contractile responses to muscarinic stimulation of urinary bladder strips from young rats and aged rats were compared.1. The EC 50 values of the two groups in response to bethanechol were similar.2. The magnitude and the velocity of tension generation was significantly lower in strips from the aged group.3. The magnitude as well as the velocity of tension generation...
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