Wyniki wyszukiwania dla: Estela Maria Lammel
Acta Tropica > 2015 > 152 > C > 8-16
Molecular & Biochemical Parasitology > 2013 > 187 > 2 > 77-86
Parasitology Research > 2009 > 105 > 1 > 47-55
artykuł
Cristian Gabriel Miranda,
Maria Elisa Solana,
Maria de los Angeles Curto,
Estela Maria Lammel,
więcej
Chagas disease is a major unsolved health issue in Latin America and an emerging threat worldwide. New drugs are urgently needed for chemotherapy as those available (benznidazole and nifurtimox) have variable efficacy and elevated toxicity. Efforts are actually oriented to improve tools and technologies (e.g. transgenic parasites, flow cytometry or image-based systems) for the screening of large numbers...
artykuł
María Laura Belaunzarán,
Silvina Elizabeth Wilkowsky,
Estela María Lammel,
Guadalupe Giménez,
więcej
Phospholipase A 1 (PLA 1 ) has been described in the infective stages of Trypanosoma cruzi as a membrane-bound/secreted enzyme that significantly modified host cell lipid profile with generation of second lipid messengers and concomitant activation of protein kinase C. In the present work we determined higher levels of PLA 1 expression in the infective amastigotes and trypomastigotes...
artykuł
Previously, we showed that oleic acid (OA) induces Trypanosoma cruzi metacyclogenesis through a signaling pathway involving de novo diacylglycerol biosynthesis and simultaneous protein kinase C (PKC) activation. Herein, we demonstrated that OA also triggers a transient Ca2+ signal in epimastigotes, necessary for parasite differentiation, that could account for PKC activation. In addition, we found...
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