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Previously, we showed that oleic acid (OA) induces Trypanosoma cruzi metacyclogenesis through a signaling pathway involving de novo diacylglycerol biosynthesis and simultaneous protein kinase C (PKC) activation. Herein, we demonstrated that OA also triggers a transient Ca2+ signal in epimastigotes, necessary for parasite differentiation, that could account for PKC activation. In addition, we found...
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