Search results for: Lewis L. Lanier

Items from 1 to 20 out of 76 results

article

Hepatocellular carcinoma after direct‐acting antivirals for hepatitis C is associated with KIR‐HLA types predicting weak NK cell‐mediated immunity

James C. Ryan, Christina Haight, Erene C. Niemi, Joshua D. Grab, more

European Journal of Immunology > 54 > 8 > n/a - n/a

Background and aims Second‐generation direct‐acting antivirals (2G DAA) to cure HCV have led to dramatic clinical improvements. HCV‐associated hepatocellular carcinoma (HCC), however, remains common. Impaired immune tumor surveillance may play a role in HCC development. Our cohort evaluated the effects of innate immune types and clinical variables on outcomes including HCC. Methods Participants...

article

ITAM‐based receptors in natural killer cells

Oscar A. Aguilar, Lam‐Kiu Fong, Lewis L. Lanier

Immunological Reviews > 323 > 1 > 40 - 53

The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by demonstrating that they can also gain adaptive features. This has been observed in both humans and mice during infection with cytomegalovirus (CMV)...

article

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter‐Instrument Variability of the Helios Mass Cytometer

Brian H. Lee, Geoffrey Kelly, Shermineh Bradford, Melanie Davila, more

Cytometry Part A > 95 > 9 > 1019 - 1030

Mass cytometry is a powerful tool for high‐dimensional single cell characterization. Since the introduction of the first commercial CyTOF mass cytometer by DVS Sciences in 2009, mass cytometry technology has matured and become more widely utilized, with sequential platform upgrades designed to address specific limitations and to expand the capabilities of the platform. Fluidigm's third‐generation...

article

Caspase-8 restricts natural killer cell accumulation during MCMV Infection

Yanjun Feng, Lisa P. Daley-Bauer, Linda Roback, Marc Potempa, more

Medical Microbiology and Immunology > 2019 > 208 > 3-4 > 543-554

Natural killer (NK) cells provide important host defense against herpesvirus infections and influence subsequent T cell control of replication and maintenance of latency. NK cells exhibit phases of expansion, contraction and memory formation in response to the natural mouse pathogen murine cytomegalovirus (MCMV). Innate and adaptive immune responses are tightly regulated in mammals to avoid excess...

article

NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration

Kasper Vadstrup, Elisabeth Douglas Galsgaard, Helle Jensen, Lewis L. Lanier, more

Experimental and Molecular Pathology > 2017 > 103 > 1 > 56-70

Interaction between the activating NKG2D receptor on lymphocytes and its ligands MICA, MICB, and ULBP1–6 modulate T and NK cell activity and may contribute to the pathogenesis of Crohn's disease (CD). NKG2D ligands are generally not expressed on the cell surface of normal, non-stressed cells, but expression of MICA and MICB in CD intestine has been reported. In this exploratory study, we further characterize...

article

NK cells in host responses to viral infections

Viola C Lam, Lewis L Lanier

Current Opinion in Immunology > 2017 > 44 > C > 43-51

Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in viral clearance. NK cell responses to viral infections were originally believed to be non-specific and lacked immune memory recall responses. It is now appreciated that NK cell responses to viral infections can be specific and in some cases memory recall responses are established. Increasing evidence also illuminates...

article

Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection

Tsukasa Nabekura, Lewis L. Lanier

Immunity > 2016 > 45 > 1 > 74-82

Natural killer (NK) cells are important in host defense against pathogens, and they can subsequently differentiate into memory NK cells. The Ly49 and KIR gene families in rodents and humans encode both inhibitory and activating receptors for MHC class I. The physiological role of activating KIR or Ly49 receptors that recognize self-MHC class I during immune response to viral infections is unknown...

chapter

NKG2D in Innate and Adaptive Immunity

Lewis L. Lanier

Advances in Experimental Medicine and Biology > Mechanisms of Lymphocyte Activation and Immune Regulation X > 51-56

The term “NK receptors” has been applied to a growing number of cell surface receptors that were initially identified by their expression on NK cells. However, it is becoming increasingly obvious that few or none of the known “NK receptors” are completely restricted in expression to NK cells. For example, many of the inhibitory mouse Ly49 receptors were in fact originally cloned from T cell lines...

chapter

Natural Killer Cell Licensing During Viral Infection

Mark T. Orr, Lewis L. Lanier

Advances in Experimental Medicine and Biology > Crossroads between Innate and Adaptive Immunity III > 37-44

Natural Killer (NK) cell functionality is controlled by inhibitory receptors that recognize self-MHC class I. NK cells that do not interact with self-MHC class I are hypo-responsive to many stimuli and fail to reject MHC class I-deficient cells. Thus, although the mechanisms are unknown, interactions with MHC class I “licensed” NK cells respond efficiently. Surprisingly, these licensed NK cells fail...

chapter

Inhibitory Ly49 Receptors on Mouse Natural Killer Cells

Mark T. Orr, Lewis L. Lanier

Current Topics in Microbiology and Immunology > Negative Co-Receptors and Ligands > 67-87

The Ly49 receptors, which are expressed in a stochastic manner on subsets of murine natural killer (NK) cells, T cells, and other cells, are encoded by the Klra gene family and include receptors with either inhibitory or activating function. All of the inhibitory Ly49 receptors are characterized by an immunoreceptor tyrosine-based inhibitory motif in their cytoplasmic domain, which upon phosphorylation...

article

Natural Killer Cell Memory

Timothy E. O’Sullivan, Joseph C. Sun, Lewis L. Lanier

Immunity > 2015 > 43 > 4 > 634-645

Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence...

article

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species

Xinfang Huang, Jingjing Li, Stephanie Dorta-Estremera, Jeremy Di Domizio, more

Cell Reports > 2015 > 12 > 7 > 1120-1132

Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by natural killer (NK) cells. IFN-α/β produced by pDCs activated NK cells via IL-15 induction. Neutrophils...

article

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

Jaewon Lee, Tianxiang Zhang, Ilwoong Hwang, Ahrom Kim, more

Immunity > 2015 > 42 > 3 > 431-442

Long-lived “memory-like” NK cells have been identified in individuals infected by human cytomegalovirus (HCMV), but little is known about how the memory-like NK cell pool is formed. Here, we have shown that HCMV-infected individuals have several distinct subsets of memory-like NK cells that are often deficient for multiple transcription factors and signaling proteins, including tyrosine kinase SYK,...

article

Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage

Yosuke Kamimura, Lewis L. Lanier

Cell Reports > 2015 > 10 > 2 > 280-291

Recent studies have demonstrated that natural killer (NK) cells are able to undergo clonal expansion and contraction and to generate self-renewing memory cells after infection with mouse cytomegalovirus (MCMV). It is unclear whether all or only certain subsets preferentially contribute to the generation of memory NK cells. Here, we show that memory NK cells predominantly arise from killer cell lectin-like...

article

Rapid and sequential quantitation of salivary gland-associated mouse cytomegalovirus in oral lavage

Yosuke Kamimura, Lewis L. Lanier

Journal of Virological Methods > 2014 > 205 > Complete > 53-56

Cytomegalovirus (CMV) establishes a persistent infection in the salivary glands and transmits to other hosts. Mouse cytomegalovirus (MCMV) is a well-characterized model for studying the mechanisms of host responses against CMV. The viral load in salivary glands has been measured traditionally because it has been considered to reflect the consequence of anti-virus responses by T cells and natural killer...

article

Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

Tsukasa Nabekura, Minoru Kanaya, Akira Shibuya, Guo Fu, more

Immunity > 2014 > 40 > 2 > 225-234

Recent studies demonstrate that natural killer (NK) cells have adaptive immune features. Here, we investigated the role of the costimulatory molecule DNAM-1 in the differentiation of NK cells in a mouse model of cytomegalovirus (MCMV) infection. Antibody blockade of DNAM-1 suppressed the expansion of MCMV-specific Ly49H⁺ cells during viral infection and inhibited the generation of memory NK cells...

article

Beyond the transcriptome: completion of act one of the Immunological Genome Project

Charles C Kim, Lewis L Lanier

Current Opinion in Immunology > 2013 > 25 > 5 > 593-597

The Immunological Genome Consortium has generated a public resource (www.immgen.org) that provides a compendium of gene expression profiles of ∼270 leukocyte subsets in the mouse. This effort established carefully standardized operating procedures that resulted in a transcriptional dataset of unprecedented comprehensiveness and quality. The findings have been detailed recently in a series of publications...

article

CEACAM1 on activated NK cells inhibits NKG2D‐mediated cytolytic function and signaling

Shuhei Hosomi, Zhangguo Chen, Kristi Baker, Lanfen Chen, more

European Journal of Immunology > 43 > 9 > 2473 - 2483

Carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is expressed on activated natural killer (NK) cells wherein it inhibits lysis of CEACAM1‐bearing tumor cell lines. The mechanism for this is unknown. Here, we show that interleukin‐2‐induced expression of CEACAM1 on both mouse and primary human NK cells impairs the ability of NK gene complex group 2 member D (NKG2D) to stimulate cytolysis...

article

Natural killer cells: walking three paths down memory lane

Gundula Min-Oo, Yosuke Kamimura, Deborah W. Hendricks, Tsukasa Nabekura, more

Trends in Immunology > 2013 > 34 > 6 > 251-258

Immunological memory has traditionally been regarded as a unique feature of the adaptive immune response, mediated in an antigen-specific manner by T and B lymphocytes. All other hematopoietic cells, including natural killer (NK) cells, are classified as innate immune cells, which have been considered short-lived but can respond rapidly against pathogens in a manner not thought to be driven by antigen...

article

MicroRNA function in NK‐cell biology

Aimee M. Beaulieu, Natalie A. Bezman, Jang Eun Lee, Mehrdad Matloubian, more

Immunological Reviews > 253 > 1 > 40 - 52

The important role of microRNAs in directing immune responses has become increasingly clear. Here, we highlight discoveries uncovering the role of specific microRNAs in regulating the development and function of natural killer (NK) cells. Furthermore, we discuss the impact of NK cells on the entire immune system during global and specific microRNA ablation in the settings of inflammation, infection,...

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INFONA - science communication portal

Search results for: Lewis L. Lanier

Hepatocellular carcinoma after direct‐acting antivirals for hepatitis C is associated with KIR‐HLA types predicting weak NK cell‐mediated immunity

ITAM‐based receptors in natural killer cells

A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter‐Instrument Variability of the Helios Mass Cytometer

Caspase-8 restricts natural killer cell accumulation during MCMV Infection

NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration

NK cells in host responses to viral infections

Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection

NKG2D in Innate and Adaptive Immunity

Natural Killer Cell Licensing During Viral Infection

Inhibitory Ly49 Receptors on Mouse Natural Killer Cells

Natural Killer Cell Memory

Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species

Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals

Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage

Rapid and sequential quantitation of salivary gland-associated mouse cytomegalovirus in oral lavage

Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection

Beyond the transcriptome: completion of act one of the Immunological Genome Project

CEACAM1 on activated NK cells inhibits NKG2D‐mediated cytolytic function and signaling

Natural killer cells: walking three paths down memory lane

MicroRNA function in NK‐cell biology

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