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Recently, poly(acrylic acid)-cysteine (PAA-cys) based formulations have shown to modulate vitamin B12 absorption across Caco-2 cells monolayers and rat intestinal mucosa. The aim of the present study was to provide a proof-of-principle for a delivery system based on PAA-cys in vivo by administering vitamin B12 to Sprague Dawley rats. In vitro, the permeation enhancing effect of unmodified and thiolated...
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