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β 1 - and β 2 -adrenoceptors (AR) are polymorphic. β 1 -AR: There is a Gly389Arg polymorphism of the β 1 -AR with the Gly389 exhibiting reduced in vitro responsiveness upon agonist-induced stimulation. To study this in vivo we assessed exercise-induced increase in heart rate and shortening of heart rate-corrected duration of electromechanical systole (QS 2 c-a...
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