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We previously showed that antral gastric tumors develop in gastrin-deficient (Gas −/− ) mice. Therefore Gas −/− mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation. Fundic atrophy developed by 9 months in Gas −/− mice. Antral mucosal hyperplasia developed coincident with the focal loss of TFF1 and Muc5AC. Microarray...
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