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Lysophosphatidic acid (LPA) is a potent inducer of colon cancer and LPA receptor type 2 (LPA 2 ) is overexpressed in colon tumors. LPA 2 interacts with membrane-associated guanylate kinase with inverted orientation-3 (MAGI-3) and the Na+/H+ exchanger regulatory factor 2 (NHERF-2), but the biological effects of these interactions are unknown. We investigated the roles of MAGI-3 and...
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