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The effects of a novel N-methyladamantan-1-amine derivative [(−)-MR22] with high σ 1 receptor affinity were investigated on retinal degeneration using a rat model of ischemia–reperfusion injury. The animals were anaesthetized and retinal ischemia was induced by elevating the intraocular pressure to 120 mm Hg for 45 min. The drug was injected intraperitoneally before the ischemic damage. Retinal...
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