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This study compared in males and females of three representative ages: young adults (3–5months old), middle-aged (12–15months old) and senescent (23–25months old) the antidepressant-like effect of fluoxetine (FLX, 5.0 and 10mg/kg) in the forced swim test (FST). Intact (non gonadectomized) rats were evaluated. Young adult females were chosen in proestrus/estrus or in metestrus/diestrus, while middle-aged...
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