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Type 1 collagen is the major extracellular protein in bone, tendons, ligaments, and skin. DNA elements of the mouse pro-α1 (I) collagen promoter were shown to drive the bone-selective expression of a luciferase transgene. We examined whether this expression can be used to evaluate the effect of anabolic agents on bone formation in vivo. Treatment of either intact males, intact females, or ovariectomized...
Alendronate (ALN; 4-amino-1-hydroxybutylidene-1,1-bisphosphonate) is a potent inhibitor of bone resorption used in the treatment of osteoporosis. Its molecular mode of action is not known. Given its bisphosphonate (BP) structure, we examined ALN effects on various phosphate transfer reactions and found that up to millimolar concentrations it did not inhibit the activities of serine/threonine phosphatase...
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