Search results for: Stuart B. Goodman

Items from 1 to 20 out of 164 results

article

Host and microbial characteristics associated with recurrent prosthetic joint infections

Jessica P. Hampton, Joanne Y. Zhou, Floriane Ngako Kameni, Joseph Raymund Espiritu, more

Journal of Orthopaedic Research® > 42 > 3 > 560 - 567

Approximately 20% of patients after resection arthroplasty and antibiotic spacer placement for prosthetic joint infection develop repeat infections, requiring an additional antibiotic spacer before definitive reimplantation. The host and bacterial characteristics associated with the development of recurrent infection is poorly understood. A case‐control study was conducted for 106 patients with intention...

article

The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section

Edward M. Schwarz, Nathan K. Archer, Gerald J. Atkins, Karen L. de Mesy Bentley, more

Journal of Orthopaedic Research® > 42 > 3 > 518 - 530

Musculoskeletal infections (MSKI), which are a major problem in orthopedics, occur when the pathogen eludes or overwhelms the host immune system. While effective vaccines and immunotherapies to prevent and treat MSKI should be possible, fundamental knowledge gaps in our understanding of protective, nonprotective, and pathogenic host immunity are prohibitive. We also lack critical knowledge of how...

article

TET1 Regulates Skeletal Stem–Cell Mediated Cartilage Regeneration

Akshay Pandey, Malachia Hoover, Mamta Singla, Yudhishtar Bedi, more

Arthritis & Rheumatology > 76 > 2 > 216 - 230

Objective Adult skeletal stem cells (SSCs) that give rise to chondrocytes, osteocytes, and stromal cells as progeny have been shown to contribute to cartilage regeneration in osteoarthritis (OA). Understanding extrinsic and intrinsic regulators of SSC fate and function can therefore identify putative candidate factors to enhance cartilage regeneration. This study explores how the DNA hydroxymethylase...

article

Preclinical models for studying corticosteroid‐induced osteonecrosis of the femoral head

Masanori Tsubosaka, Masahiro Maruyama, Elaine Lui, Junichi Kushioka, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 112 > 1 > n/a - n/a

Nontraumatic osteonecrosis of the femoral head (ONFH) is a refractory condition that commonly results in femoral head collapse and degenerative arthritis of the hip. In the early stages, surgical procedures for hip preservation, including core decompression (CD), have been developed to prevent progressive collapse of the femoral head. Optimization of bone regeneration and biological augmentation may...

article

Selecting a high‐dose antibiotic‐laden cement knee spacer

Ian Hollyer, David Ivanov, Shanthi Kappagoda, David W. Lowenberg, more

Journal of Orthopaedic Research® > 41 > 7 > 1383 - 1396

Prosthetic joint infection [PJI] after total knee arthroplasty (TKA) remains a common and challenging problem for joint replacement surgeons and patients. Once the diagnosis of PJI has been made, patient goals and characteristics as well as the infection timeline dictate treatment. Most commonly, this involves a two‐stage procedure with the removal of all implants, debridement, and placement of a...

article

Therapeutic effects of MSCs, genetically modified MSCs, and NFĸB‐inhibitor on chronic inflammatory osteolysis in aged mice

Junichi Kushioka, Masakazu Toya, Huaishuang Shen, Hirohito Hirata, more

Journal of Orthopaedic Research® > 41 > 5 > 1004 - 1013

The number of total joint replacements is increasing, especially in elderly patients, and so too are implant‐related complications such as prosthesis loosening. Wear particles from the prosthesis induce a chronic inflammatory reaction and subsequent osteolysis, leading to the need for revision surgery. This study investigated the therapeutic effect of NF‐ĸB decoy oligodeoxynucleotides (ODN), mesenchymal...

article

Applying deep learning to quantify empty lacunae in histologic sections of osteonecrosis of the femoral head

Elaine Lui, Masahiro Maruyama, Roberto A. Guzman, Seyedsina Moeinzadeh, more

Journal of Orthopaedic Research® > 40 > 8 > 1801 - 1809

Osteonecrosis of the femoral head (ONFH) is a disease in which inadequate blood supply to the subchondral bone causes the death of cells in the bone marrow. Decalcified histology and assessment of the percentage of empty lacunae are used to quantify the severity of ONFH. However, the current clinical practice of manually counting cells is a tedious and inefficient process. We utilized the power of...

article

The efficacy of core decompression for steroid‐associated osteonecrosis of the femoral head in rabbits

Masahiro Maruyama, Tzuhua Lin, Nicolas I. Kaminow, Timothy Thio, more

Journal of Orthopaedic Research® > 39 > 7 > 1441 - 1451

Although core decompression (CD) is often performed in the early stage of osteonecrosis of the femoral head (ONFH), the procedure does not always prevent subsequent deterioration and the effects of CD are not fully clarified. The aim of this study is to evaluate the efficacy of CD for steroid‐associated ONFH in rabbits. Twelve male and 12 female New Zealand rabbits were injected intramuscularly 20...

article

Selective screw fixation is associated with early failure of primary acetabular components for aseptic loosening

L. Henry Goodnough, John C. Bonano, Andrea K. Finlay, Vinay K. Aggarwal, more

Journal of Orthopaedic Research® > 38 > 11 > 2429 - 2433

Selective supplementation of acetabular component fixation with a screw during primary total hip arthroplasty (THA) assumes that the surgeon can detect when an acetabular component needs additional stability. In contrast, nonselective screw users do not alter their practice based on their interpretation of stability and either use screws all or none of the time. We aimed to determine the effect of...

article

Recent advances in total joint replacement

Stuart B. Goodman, Markus A. Wimmer, Heidi‐Lynn Ploeg

Journal of Orthopaedic Research® > 38 > 7 > 1413 - 1413

article

Effect of Aging on the Macrophage Response to Titanium Particles

Eemeli Jämsen, Jukka Pajarinen, Tzu‐hua Lin, Chi‐Wen Lo, more

Journal of Orthopaedic Research® > 38 > 2 > 405 - 416

Macrophage‐mediated inflammatory reaction to implant wear particles drives bone loss around total joint replacements (TJR). Although most TJR recipients are elderly, studies linking wear particle‐activated macrophages and peri‐implant osteolysis have not taken into account the multiple effects that aging has on the innate immune system and, in particular, on macrophages. To address this, we compared...

article

Angiotensin receptor blockade mimics the effect of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration

Vivianne L. Tawfik, Marco Quarta, Patrick Paine, Thomas E. Forman, more

The Journal of Physiology > 598 > 2 > 317 - 329

Key points Our tibial fracture orthopaedic injury model in mice recapitulates the major manifestations of complex trauma, including nociceptive sensitization, bone fracture, muscle fibrosis and muscle fibre loss. Delayed exercise after complex orthopaedic trauma results in decreased muscle fibrosis and improved pain Losartan, an angiotensin‐receptor blocker with anti‐fibrotic abilities, recapitulates...

article

Strontium enhances BMP‐2 mediated bone regeneration in a femoral murine bone defect model

Mandy Quade, Corina Vater, Saskia Schlootz, Julia Bolte, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 108 > 1 > 174 - 182

The application of strontium is one option for the clinical treatment of osteoporosis—a disease characterized by reduced bone density and quality—in order to reduce the risk of vertebral and nonvertebral fractures. Unlike other drugs used in osteoporosis therapy, strontium shows a dual effect on bone metabolism by attenuating cellular resorption and simultaneously enhancing new bone tissue formation...

article

Osteogenic ability of rat bone marrow concentrate is at least as efficacious as mesenchymal stem cells in vitro

Yusuke Kohno, Tzuhua Lin, Jukka Pajarinen, Monica Romero‐Lopez, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 107 > 8 > 2500 - 2506

Cell therapy using bone marrow concentrate (BMC) or purified and expanded mesenchymal stem cells (MSCs) has been shown to have a promising osteogenic capacity. However, few studies have directly compared their relative osteogenic ability. The aim of this study was to compare the osteogenic ability of BMC isolated by density gradient centrifugation with bone marrow‐derived MSCs in vitro using the cells...

article

Two‐step stem cell therapy improves bone regeneration compared to concentrated bone marrow therapy

Julia Bolte, Corina Vater, Anna Carla Culla, Tilman Ahlfeld, more

Journal of Orthopaedic Research® > 37 > 6 > 1318 - 1328

Adult stem cells are a promising tool to positively influence bone regeneration. Concentrated bone marrow therapy entails isolating osteoprogenitor cells during surgery with, however, only low cells yield. Two step stem cell therapy requires an additional harvesting procedure but generates high numbers of progenitor cells that facilitate osteogenic pre‐differentiation. To further improve bone regeneration,...

article

Suboptimal patellofemoral alignment is associated with poor clinical outcome scores after primary total knee arthroplasty

Rapeepat Narkbunnam, Ali J. Electricwala, James I. Huddleston, William J. Maloney, more

Archives of Orthopaedic and Trauma Surgery > 2019 > 139 > 2 > 249-254

Background Proper patellofemoral alignment is an important goal in total knee arthroplasty (TKA). Acceptable patellar alignment is defined as patellar tilt less than or equal to 5° and patellar displacement less than or equal to 5 mm. Previous studies reported an incidence of post-operative patellar malalignment in TKA from 7 to 35%. However, correlation between patellar malalignment and clinical...

article

Periprosthetic bacterial biofilm and quorum sensing

Jake A. Mooney, Eric M. Pridgen, Robert Manasherob, Gina Suh, more

Journal of Orthopaedic Research® > 36 > 9 > 2331 - 2339

Periprosthetic joint infection (PJI) is a common complication after total joint arthroplasty leading to severe morbidity and mortality. With an aging population and increasing prevalence of total joint replacement procedures, the burden of PJI will be felt not only by individual patients, but in increased healthcare costs. Current treatment of PJI is inadequate resulting in incredibly high failure...

article

Protocol-Driven Revision for Stiffness After Total Knee Arthroplasty Improves Motion and Clinical Outcomes

Kevin T. Hug, Derek F. Amanatullah, James I. Huddleston, William J. Maloney, more

The Journal of Arthroplasty > 2018 > 33 > 9 > 2952-2955

Stiffness after revision total knee arthroplasty (TKA) is a difficult problem without a well-defined treatment algorithm. The purpose of this study was to evaluate the results of revision TKA for stiffness within the context of differential component replacement.Consecutive patients who underwent revision TKA were retrospectively identified and included those who received debridement and polyethylene...

article

Low intrapatient variability of histomorphological findings in periprosthetic tissues from revised metal/ceramic on polyethylene joint arthroplasties

Jana Vaculova, Jiri Gallo, Pavel Hurnik, Oldrich Motyka, more

Journal of Biomedical Materials Research Part B: Applied Biomaterials > 106 > 5 > 2008 - 2018

The type of tissue response to implant by‐products can be determined by examination of periprosthetic tissues. However, little is known about the most suitable location for tissue sampling. The main goal of this study was to evaluate the extent of variability in tissue response in relation to location of tissue sampling, implant fixation, age and sex in total joint arthroplasties with metal‐on‐polyethylene...

article

A Tissue Engineering Approach for Treating Early Osteonecrosis of the Femoral Head

Stuart B. Goodman

Regenerative Engineering and Translational Medicine > 2018 > 4 > 3 > 162-166

Early osteonecrosis of the femoral head (ONFH), without structural collapse or subsequent degeneration of the overlying articular cartilage, presents the clinician with an opportunity to save the hip joint and thus avoid joint replacement surgery. To accomplish this goal, core decompression, in which the osteonecrotic segment of the femoral head is drilled, was devised. This operation stimulates a...

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INFONA - science communication portal

Search results for: Stuart B. Goodman

Host and microbial characteristics associated with recurrent prosthetic joint infections

The 2023 Orthopaedic Research Society's International Consensus Meeting on musculoskeletal infection: Summary from the host immunity section

TET1 Regulates Skeletal Stem–Cell Mediated Cartilage Regeneration

Preclinical models for studying corticosteroid‐induced osteonecrosis of the femoral head

Selecting a high‐dose antibiotic‐laden cement knee spacer

Therapeutic effects of MSCs, genetically modified MSCs, and NFĸB‐inhibitor on chronic inflammatory osteolysis in aged mice

Applying deep learning to quantify empty lacunae in histologic sections of osteonecrosis of the femoral head

The efficacy of core decompression for steroid‐associated osteonecrosis of the femoral head in rabbits

Selective screw fixation is associated with early failure of primary acetabular components for aseptic loosening

Recent advances in total joint replacement

Effect of Aging on the Macrophage Response to Titanium Particles

Angiotensin receptor blockade mimics the effect of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration

Strontium enhances BMP‐2 mediated bone regeneration in a femoral murine bone defect model

Osteogenic ability of rat bone marrow concentrate is at least as efficacious as mesenchymal stem cells in vitro

Two‐step stem cell therapy improves bone regeneration compared to concentrated bone marrow therapy

Suboptimal patellofemoral alignment is associated with poor clinical outcome scores after primary total knee arthroplasty

Periprosthetic bacterial biofilm and quorum sensing

Protocol-Driven Revision for Stiffness After Total Knee Arthroplasty Improves Motion and Clinical Outcomes

Low intrapatient variability of histomorphological findings in periprosthetic tissues from revised metal/ceramic on polyethylene joint arthroplasties

A Tissue Engineering Approach for Treating Early Osteonecrosis of the Femoral Head

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