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The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3 position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of physiological functions, affecting GH release, food intake, energy and glucose homeostasis, gastrointestinal, cardiovascular, pulmonary and immune function, cell proliferation and differentiation and bone physiology. Nevertheless,...
Contractile effects of ghrelin (10 −9 to 10 −6 M) were tested in rat papillary muscles of normal (n=50) and hypertrophic (n=16) right ventricles (RV). RV hypertrophy was induced by pulmonary hypertension using monocrotaline. In normal muscles, ghrelin was added either alone (n=9) or after pre-treatment with indomethacin (cycloxygenase inhibitor, 10 −5 M; n=10), l-nitro-l-arginin...
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