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The aim of this work was to investigate if the indomethacin ethyl ester (IndOEt) released from lipid-core nanocapsules (NC) is converted into indomethacin (IndOH) in the intestine lumen, intestine wall or after the particles reach the blood stream. NC–IndOEt had monomodal size distribution (242nm; PDI 0.2) and zeta potential of −11mV. The everted rat gut sac model showed IndOEt passage of 0.16μmolm...
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