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The critical genes and products involved in estrogen-induced tumorigenesis of the pituitary gland were investigated in heterozygous transforming growth factor-β (TGF-β) receptor type II and p27 knockout mouse models. Tgfbr2(+/−), p27(+/−); Tgfbr2(+/−), and p27(+/−) mice and C57BL/6J wild-type mice received sc implantation of estrogen or placebo pellets for 16 or 25 wk, after which the mice were sacrificed...
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