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The binding of [ 123 I]AM251 (a radioiodinated analog of the cannabinoid CB1 receptor antagonist SR141716A) was compared to that of [ 3 H]CP 55,940 in mouse and rat brain preparations. Scatchard analysis of the binding of [ 123 I]AM251 and [ 3 H]CP 55,940 to membranes prepared from mouse cerebellum, striatum and hippocampus yielded similar Bmax...
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