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The subthalamic nucleus occupies a position in the indirect pathway of basal ganglia circuit, which plays an important role in the movement regulation. Zolpidem is an imidazopyridine agonist with a high affinity on the benzodiazepine site of GABA A receptors containing α 1 subunit. Recently, zolpidem has been reported to be useful in treating subgroups of parkinsonian patients. A high density...
The globus pallidus is believed to play a critical role in the normal function of the basal ganglia, and abnormal activity of its neurons may underlie some basal ganglia motor symptoms. A high density of benzodiazepine binding sites on GABA A receptors has been reported in the rat globus pallidus. The present study investigates the effect of activating the benzodiazepine site by the agonist...
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