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The globus pallidus plays a critical role in movement regulation. Morphological studies have shown that group I mGluRs including mGluR1 and mGluR5 are expressed in the globus pallidus. Up to now, little is known about the in vivo electrophysiological effects of group I mGluRs on the pallidal neurons. The present study investigated the electrophysiological effects of group I mGluRs on the firing rate...
Whole-cell recordings from rat midbrain slices showed that bath application of taurine (30 μM-10 mM) reversibly hyperpolarized and inhibited the firing of substantia nigra pars reticulata neurons. These effects were mediated by an increase in membrane chloride conductance. Taurine cross-desensitized with GABA and glycine. Strychnine competitively antagonized the actions of glycine and taurine but...
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