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Objectives
Kallikrein 7 (KLK7) is a secreted serine protease that plays important roles in skin desquamation and tumour progression, which makes it an attracting drug target. To guide the design of KLK7 inhibitors, a series of coumarin‐based inhibitors were used to perform 3D‐quantitative structure–activity relationship analysis.
Methods
3D conformations of 37 inhibitors were generated and used...
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