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Hormesis describes an adaptive process to resist stress. It is characterized by the biphasic response to 1000s of compounds, including natural signaling molecules. The underlying molecular pathways are activated by both exercise and calorie restriction and appear to slow the aging process by upregulating somatic maintenance, mitochondrial function, and oxidant resistance. The origins of this are ancient...
The archaeal basal transcription machinery resembles the core components of the eucaryal RNA polymerase II apparatus. Thus, studies of the archaeal basal machinery over the last few years have shed light on fundamentally conserved aspects of the mechanisms of transcription pre-initiation complex assembly in both eucarya and archaea. Intriguingly, it has become increasingly apparent that regulators...
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