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Basic cognitive functions, such as the abilities to activate, represent, maintain, focus and process information, decline with age. A paradigm shift towards cross-level conceptions is needed in order to obtain an integrative understanding of cognitive aging phenomena that cuts across neural, information-processing, and behavioral levels. We review empirical data at these different levels, and computational...
An integrative theory relating cognitive aging deficits observed at the behavioral level with age-related deficiency in neuromodulation causing less distinctive cortical representations is tested in a series of neural network simulations. Age-related attenuation of catecholaminergic function is simulated by lowering the mean gain of the processing unit, which subsequently reduces responsivity and...
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