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NPFF precursor, pro-NPFF A contains three known bioactive sequences: NPFF (FLFQPQRF-NH 2 ), neuropeptide AF (NPAF; AGEGLSSPFWSLAAPQRF-NH 2 ) and neuropeptide SF (NPSF; SLAAPQRF-NH 2 ). The key-feature of these fragments is their common PQRF-amidated sequence at their C termini. Here, we evaluated the biological activity of two other sequences derived from the mouse...
Neuropeptide FF (NPFF) precursors from different species contain at least three known neuropeptides, i.e. FF (FLFQPQRF-NH 2 ), AF (AGEGLSSPFWSLAAPQR-NH 2 ) and SF (SLAAPQRF-NH 2 ). We demonstrate that the rat NPFF precursor contains another bioactive sequence, NAWGPWSKEQLSPQA, spanning between positions 85 and 99. Synthetic NPFF precursor (85–99) (10 and 20nmol, i.c.v.) blocked...
A C-terminal analog of the hexapeptide orphanin FQ/nociceptin-(1-6), [Ala 6 ]-orphanin FQ/nociceptin-(1-6), and a pentapeptide orphanin FQ/nociceptin-(1-5) were tested in vivo for their analgesic/hyperalgesic activity in the hot-plate test with rats. Replacement of the C-terminal glycine by l-alanine (Phe-Gly-Gly-Phe-Thr-Ala) in orphanin FQ/nociceptin-(1-6) abolished the hyperalgesic potency...
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