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Synthetic derivative of C-terminal fragment of CART (55–102) with reduced thiol groups, [Abu 86,94 ]CART (85–102) red , given together with amphetamine (5mg/kg, s.c.) or cocaine (15mg/kg, s.c.), reversed hyperlocomotion induced by these drugs at a dose of 0.1μg but not at a higher dose. In the cerebral cortex homogenate, [Abu 86,94 ]CART (85–102) red was nonspecifically...
Cocaine- and amphetamine-regulated transcript (CART) peptides attracted much attention after the discovery that the level of CART mRNA is increased in rat striatum after acute administration of cocaine and amphetamine. The most widely investigated sequence is CART (55–102), whose roles were confirmed in modulation of various physiological processes such as feeding, energy expenditure, stress control,...
Nociceptin (also called orphanin FQ), a 17-amino-acid peptide, is the natural ligand of the nociceptin opioid peptide (NOP) receptor. This peptide shows similarities, in its structure, to opioid peptides, mainly to dynorphin A. However, unlike opioid peptides, it does not produce a conditioned place preference or aversion but inhibits rewarding effect of drugs of abuse. The present study was designed...
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