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Die Dimerisierung von STAT3 …︁ (“signal transducer and activator of transcription 3”) kann durch einen substitutionsinerten metallorganischen Gruppe‐9‐Komplex direkt gehemmt werden, wie D.‐L. Ma, C.‐H. Leung, H.‐M. D. Wang und Mitarbeiter in ihrer Zuschrift auf S. 9332 ff. berichten. Der cyclometallierte Rhodium(III)‐Komplex wirkt auf die SH2‐Domäne von STAT3 und weist eine selektive Antitumoraktivität...
Kinetically inert metal complexes have arisen as promising alternatives to existing platinum and ruthenium chemotherapeutics. Reported herein, to our knowledge, is the first example of a substitutionally inert, Group 9 organometallic compound as a direct inhibitor of signal transducer and activator of transcription 3 (STAT3) dimerization. From a series of cyclometalated rhodium(III) and iridium(III)...
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