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Arteriosclerosis is characterized by the local activation of effector T cells leading to production of proinflammatory cytokines, such as IFN (interferon)‐γ and IL‐17, within the vessel wall. Conversely, the production of antiinflammatory cytokines, for example, TGF‐β, by regulatory lymphocytes is known to inhibit both the differentiation of naïve T cells into effector T cells and the development...
Tissue engineered constructs containing tortuous endothelial cell-lined perfusion channels were formed by randomly assembling endothelial cell-seeded submillimeter-sized collagen cylinders (modules) into a microfluidic perfusion chamber. The interconnected void space produced by random module packing created flow channels that were lined with endothelial cells. The effect of perfusion (0.5 mL min...
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