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Abstract A traditional Japanese herbal medicine, Sho-saiko-to (SST), has been used orally to treat several chronic diseases. Since these have included allergic rhinitis and bronchial asthma, we investigated the effect of SST on histamine release and the intracellular Ca2+ response in mast cells ex vivo. A single dose of 1.0 g/kg SST was administered orally to immunized rats 212 h before death. Mast...
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